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As DNA damage accumulates with age and exercise, PARP activity increases which can deplete NAD+ rapidly

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Because B12 from food and pills may not be fully absorbed by the body, many health experts recommend taking B12 as a sublingual (under the tongue) spray

For patients balancing demanding schedules with the physical demands of hiking Sycuan Peak, or spending weekends on the water at Lake Jennings through the dry heat that settles into the Anza-Borrego-fed inland basin each summer, a targeted injection closes nutritional gaps more efficiently than pills alone

Some patients benefit from weekly injections initially, then monthly maintenance